Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: Correlation with memory functions
Identifieur interne : 002267 ( Main/Exploration ); précédent : 002266; suivant : 002268Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: Correlation with memory functions
Auteurs : P. Laakso [Finlande] ; H. Soininen [Finlande] ; K. Partanen [Finlande] ; -L. Helkala [Finlande] ; P. Hartikainen [Finlande] ; P. Vainio [Finlande] ; M. Hallikainen [Finlande] ; T. H Nninen [Finlande] ; J. Riekkinen Sr [Finlande]Source :
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section [ 0936-3076 ] ; 1995-02-01.
Abstract
Summary: We studied the usefulness of measuring volumes of the hippocampus, amygdala and frontal lobes with coronal magnetic resonance imaging (MRI) scans in the diagnosis of early Alzheimer's disease (AD). We examined 32 patients diagnosed according to the NINCDS-ADRDA criteria of probable AD and 16 age-matched healthy cognitively normal controls. The AD patients had mild dementia with a mean score of 22.8 in the Mini-Mental Status Examination (MMSE). We used a 1.5T magnetic resonance imager and normalized the volumes for brain area. The AD patients had significantly smaller volumes of the right and the left hippocampus (−38%) (ANOVA, p<0.001) and the left frontal lobe (−16%, p<0.05) compared to controls. The reductions in volumes of the right frontal lobe (−13%), the right amygdala (−14%) or the left amygdala (−18%) were not statistically significant. In the discriminant function analysis which included the volumes of the hippocampus, amygdala, and the frontal lobes and age, the volumes of the left and right hippocampus, the left and right frontal lobe, and the right amygdala entered the model and we could correctly classify 92% of the subjects into AD and control groups (Chi-square 42.6, df 5, p<0.0001). By using the volumes of the hippocampus, the frontal lobes or the amygdala on their alone, the correct classification was achieved in 88%, 65% and 58% of the subjects, respectively. In addition, in AD patients the volumes of the left hippocampus correlated significantly with the MMSE score and with immediate and delayed verbal memory; the smaller the volume the more impaired was their performance. Our data indicate that measurements of volumes of the hippocampus might be useful in diagnosis of early AD.
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DOI: 10.1007/BF02252964
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Box 1267, SF-70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Hallikainen, M" sort="Hallikainen, M" uniqKey="Hallikainen M" first="M." last="Hallikainen">M. Hallikainen</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University Hospital and University of Kuopio, P.O. Box 1627, SF-70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="H Nninen, T" sort="H Nninen, T" uniqKey="H Nninen T" first="T." last="H Nninen">T. H Nninen</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University Hospital and University of Kuopio, P.O. Box 1627, SF-70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Riekkinen Sr, J" sort="Riekkinen Sr, J" uniqKey="Riekkinen Sr J" first="J." last="Riekkinen Sr">J. Riekkinen Sr</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University Hospital and University of Kuopio, P.O. Box 1627, SF-70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>A.I. Virtanen Institute, B.O. Box 1627, SF-70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission - Parkinson's Disease and Dementia Section</title><title level="j" type="abbrev">J Neural Transm Gen Sect</title><idno type="ISSN">0936-3076</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1995-02-01">1995-02-01</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="86">86</biblScope></imprint><idno type="ISSN">0936-3076</idno></series><idno type="istex">A3A52BBB540CA64A99759B4EFFF54F976045933C</idno><idno type="DOI">10.1007/BF02252964</idno><idno type="ArticleID">Art6</idno><idno type="ArticleID">BF02252964</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0936-3076</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: We studied the usefulness of measuring volumes of the hippocampus, amygdala and frontal lobes with coronal magnetic resonance imaging (MRI) scans in the diagnosis of early Alzheimer's disease (AD). We examined 32 patients diagnosed according to the NINCDS-ADRDA criteria of probable AD and 16 age-matched healthy cognitively normal controls. The AD patients had mild dementia with a mean score of 22.8 in the Mini-Mental Status Examination (MMSE). We used a 1.5T magnetic resonance imager and normalized the volumes for brain area. The AD patients had significantly smaller volumes of the right and the left hippocampus (−38%) (ANOVA, p<0.001) and the left frontal lobe (−16%, p<0.05) compared to controls. The reductions in volumes of the right frontal lobe (−13%), the right amygdala (−14%) or the left amygdala (−18%) were not statistically significant. In the discriminant function analysis which included the volumes of the hippocampus, amygdala, and the frontal lobes and age, the volumes of the left and right hippocampus, the left and right frontal lobe, and the right amygdala entered the model and we could correctly classify 92% of the subjects into AD and control groups (Chi-square 42.6, df 5, p<0.0001). By using the volumes of the hippocampus, the frontal lobes or the amygdala on their alone, the correct classification was achieved in 88%, 65% and 58% of the subjects, respectively. In addition, in AD patients the volumes of the left hippocampus correlated significantly with the MMSE score and with immediate and delayed verbal memory; the smaller the volume the more impaired was their performance. Our data indicate that measurements of volumes of the hippocampus might be useful in diagnosis of early AD.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Laakso, P" sort="Laakso, P" uniqKey="Laakso P" first="P." last="Laakso">P. Laakso</name></noRegion><name sortKey="H Nninen, T" sort="H Nninen, T" uniqKey="H Nninen T" first="T." last="H Nninen">T. H Nninen</name><name sortKey="Hallikainen, M" sort="Hallikainen, M" uniqKey="Hallikainen M" first="M." last="Hallikainen">M. Hallikainen</name><name sortKey="Hartikainen, P" sort="Hartikainen, P" uniqKey="Hartikainen P" first="P." last="Hartikainen">P. Hartikainen</name><name sortKey="Helkala, L" sort="Helkala, L" uniqKey="Helkala " first="-L." last="Helkala">-L. Helkala</name><name sortKey="Laakso, P" sort="Laakso, P" uniqKey="Laakso P" first="P." last="Laakso">P. Laakso</name><name sortKey="Partanen, K" sort="Partanen, K" uniqKey="Partanen K" first="K." last="Partanen">K. Partanen</name><name sortKey="Riekkinen Sr, J" sort="Riekkinen Sr, J" uniqKey="Riekkinen Sr J" first="J." last="Riekkinen Sr">J. Riekkinen Sr</name><name sortKey="Riekkinen Sr, J" sort="Riekkinen Sr, J" uniqKey="Riekkinen Sr J" first="J." last="Riekkinen Sr">J. Riekkinen Sr</name><name sortKey="Soininen, H" sort="Soininen, H" uniqKey="Soininen H" first="H." last="Soininen">H. Soininen</name><name sortKey="Vainio, P" sort="Vainio, P" uniqKey="Vainio P" first="P." last="Vainio">P. Vainio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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